VEGFR1 for lymphangiogenesis: an alternative signaling pathway?
نویسنده
چکیده
The lymphatic vascular system is a conduit for interstitial fluid extravasated from blood vessels and also plays important roles in maintaining immune responses, lipid uptake, and tissue homeostasis. In recent years, much attention has been given to lymphangiogenesis, a formation of new lymphatic vessels, because lymphangiogenesis has been shown to be involved in lymph node metastasis of tumors.1
منابع مشابه
VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment.
OBJECTIVE Angiogenesis and lymphangiogenesis are complex phenomena that involve the interplay of several growth factors and receptors. Recently, we have demonstrated that in Keratin-14 (K14) promoter-driven Vegf-A transgenic (Tg) mice, not only angiogenesis but also lymphangiogenesis is stimulated. However, the mechanism by which VEGFR1 is involved in lymphangiogenesis remains unclear. METHOD...
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عنوان ژورنال:
- Arteriosclerosis, thrombosis, and vascular biology
دوره 28 4 شماره
صفحات -
تاریخ انتشار 2008